Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aurora A and Aurora B jointly coordinate chromosome segregation and anaphase microtubule dynamics.

The Journal of cell biology - 26 Dec 2011

Hégarat Nadia, Smith Ewan, Nayak Gowri, Takeda Shunichi, Eyers Patrick A, Hochegger Helfrid

Abstract excerpt

We established a conditional deletion of Aurora A kinase (AurA) in Cdk1 analogue-sensitive DT40 cells to analyze AurA knockout phenotypes after Cdk1 activation. In the absence of AurA, cells form bipolar spindles but fail to properly align their chromosomes and exit mitosis with segregation errors. The resulting daughter cells exhibit a variety of phenotypes and are highly aneuploid. Aurora B kinase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anaphase
Share to Aneuploidy
Share to Aurora Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CDC2 Protein Kinase

Share to Chickens

Share to Chromosome Segregation

Share to Microtubules

Share to Mitosis

Source

Open in PubMed Open full text

Identifiers

PMID: 22184196
DOI: 10.1083/jcb.201105058
PMCID: PMC3246887

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aurora A and Aurora B jointly coordinate chromosome segregation and anaphase microtubule dynamics.PMID 22184196Read ↗

Aurora-A Kinase Maintains the Fidelity of Early and Late Mitotic Events in HeLa CellsSemantic proximity Read ↗

Aurora-A kinase is essential for bipolar spindle formation and early development.Semantic proximity Read ↗

Aurora kinases link chromosome segregation and cell division to cancer susceptibility.Semantic proximity Read ↗

Aurora A Is Essential for Early Embryonic Development and Tumor SuppressionSemantic proximity Read ↗

The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint.Semantic proximity Read ↗

Mitotic activation of the kinase Aurora-A requires its binding partner Bora.Semantic proximity Read ↗

Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A.Semantic proximity Read ↗

Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian developmentSemantic proximity Read ↗

Aurora kinase B modulates chromosome alignment in mouse oocytesSemantic proximity Read ↗

Aurora-A: the maker and breaker of spindle poles.Semantic proximity Read ↗

The ARF tumor suppressor prevents chromosomal instability and ensures mitotic checkpoint fidelity through regulation of Aurora B.Semantic proximity Read ↗

AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.