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Article

Aurora kinase B modulates chromosome alignment in mouse oocytes

29 Jun 2009

Abstract excerpt

The elevated incidence of aneuploidy in human oocytes warrants study of the molecular mechanisms regulating proper chromosome segregation. The Aurora kinases are a well-conserved family of serine/threonine kinases that are involved in proper chromosome segregation during mitosis and meiosis. Here we report the expression and localization of all three Aurora kinase homologs, AURKA, AURKB, and AURKC, during meiotic...

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PMID: 19565641
DOI: 10.1002/mrd.21075

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