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Article

The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint.

The Journal of cell biology - 28 Apr 2003

Hauf Silke, Cole Richard W, LaTerra Sabrina, Zimmer Christine, Schnapp Gisela, Walter Rainer, Heckel Armin, van Meel Jacques, Rieder Conly L, Peters Jan-Michael

Abstract excerpt

The proper segregation of sister chromatids in mitosis depends on bipolar attachment of all chromosomes to the mitotic spindle. We have identified the small molecule Hesperadin as an inhibitor of chromosome alignment and segregation. Our data imply that Hesperadin causes this phenotype by inhibiting the function of the mitotic kinase Aurora B. Mammalian cells treated with Hesperadin enter anaphase in the presence...

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Identifiers

PMID: 12707311
DOI: 10.1083/jcb.200208092
PMCID: PMC2172906

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint.PMID 12707311Read ↗

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