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Article

Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A.

The Journal of cell biology - 12 Jul 2010

Molli Poonam R, Li Da-Qiang, Bagheri-Yarmand Rozita, Pakala Suresh B, Katayama Hiroshi, Sen Subrata, Iyer Jyoti, Chernoff Jonathan, Tsai Ming-Ying, Nair Sujit S, Kumar Rakesh

Abstract excerpt

Here we provide evidence in support of an inherent role for Arpc1b, a component of the Arp2/3 complex, in regulation of mitosis and demonstrate that its depletion inhibits Aurora A activation at the centrosome and impairs the ability of mammalian cells to enter mitosis. We discovered that Arpc1b colocalizes with gamma-tubulin at centrosomes and stimulates Aurora A activity. Aurora A phosphorylates Arpc1b on...

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Identifiers

PMID: 20603326
DOI: 10.1083/jcb.200908050
PMCID: PMC2911675

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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