Article
The ARF tumor suppressor prevents chromosomal instability and ensures mitotic checkpoint fidelity through regulation of Aurora B.
Molecular biology of the cell - 15 Sept 2014
Britigan Eric M C, Wan Jun, Zasadil Lauren M, Ryan Sean D, Weaver Beth A
Abstract excerpt
The ARF tumor suppressor is part of the CDKN2A locus and is mutated or undetectable in numerous cancers. The best-characterized role for ARF is in stabilizing p53 in response to cellular stress. However, ARF has tumor suppressive functions outside this pathway that have not been fully defined. Primary mouse embryonic fibroblasts (MEFs) lacking the ARF tumor suppressor contain abnormal numbers of chromosomes....
Topics
- Aneuploidy
- Animals
- Aurora Kinase B
- Cell Cycle Proteins
- Cells, Cultured
- Chromosomal Instability
- Cyclin-Dependent Kinase Inhibitor p16
- Enzyme Stability
- Gene Expression
- Gene Expression Regulation, Enzymologic