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Aurora A Is Essential for Early Embryonic Development and Tumor Suppression

18 Sept 2008

Abstract excerpt

Aurora A is a serine/threonine kinase that functions in various stages of mitosis. Accumulating evidence has demonstrated that gene amplification and overexpression of Aurora A are linked to tumorigenesis, suggesting that Aurora A is an oncogene. In addition, Aurora A overexpression has been used as a negative prognostic marker, because it is associated with resistance to anti-mitotic agents commonly used for...

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PMID: 18801727
DOI: 10.1074/jbc.m805880200

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