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Article

AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol.

Cancer cell - 1 Jan 2003

Anand Shubha, Penrhyn-Lowe Sue, Venkitaraman Ashok R

Abstract excerpt

The serine-threonine kinase gene AURORA-A is commonly amplified in epithelial malignancies. Here we show that elevated Aurora-A expression at levels that reflect cancer-associated gene amplification overrides the checkpoint mechanism that monitors mitotic spindle assembly, inducing resistance to the chemotherapeutic agent paclitaxel (Taxol). Cells overexpressing Aurora-A inappropriately enter anaphase despite...

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Source

Identifiers

PMID: 12559175
DOI: 10.1016/s1535-6108(02)00235-0

Genes

BUB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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