Article
Whole genome sequencing of melanomas in adolescent and young adults reveals distinct mutation landscapes and the potential role of germline variants in disease susceptibility.
International journal of cancer - 1 Mar 2019
Wilmott James S, Johansson Peter A, Newell Felicity, Waddell Nicola, Ferguson Peter, Quek Camelia, Patch Ann-Marie, Nones Katia, Shang Ping, Pritchard Antonia L, Kazakoff Stephen, Holmes Oliver, Leonard Conrad, Wood Scott, Xu Qinying, Saw Robyn P M, Spillane Andrew J, Stretch Jonathan R, Shannon Kerwin F, Kefford Richard F, Menzies Alexander M, Long Georgina V, Thompson John F, Pearson John V, Mann Graham J, Hayward Nicholas K, Scolyer Richard A
Abstract excerpt
Cutaneous melanoma accounts for at least >10% of all cancers in adolescents and young adults (AYA, 15-30 years of age) in Western countries. To date, little is known about the correlations between germline variants and somatic mutations and mutation signatures in AYA melanoma patients that might explain why they have developed a cancer predominantly affecting those over 65 years of age. We performed genomic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.