ERp44 C160S/C212S mutants regulate IP3R1 channel activity.

doi:10.1007/s13238-011-1116-0

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Article

ERp44 C160S/C212S mutants regulate IP3R1 channel activity.

Protein & cell - 1 Dec 2011

Pan Congyan, Zheng Ji, Wu Yanyun, Chen Yingxiao, Wang Likun, Zhou Zhansong, Yin Wenxuan, Ji Guangju

Abstract excerpt

Previous studies have indicated that ERp44 inhibits inositol 1,4,5-trisphosphate (IP(3))-induced Ca(2+) release (IICR) via IP(3)R(1), but the mechanism remains largely unexplored. Using extracellular ATP to induce intracellular calcium transient as an IICR model, Ca(2+) image, pull down assay, an...

Topics

Adenosine Triphosphate
Amino Acid Substitution
Biological Transport
Blotting, Western
Calcium
Calcium Signaling
HeLa Cells
Humans
Immunoprecipitation
Inositol 1,4,5-Trisphosphate
Inositol 1,4,5-Trisphosphate Receptors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Potentials

Membrane Proteins

Microscopy, Confocal

Molecular Chaperones

Mutation

Plasmids

Transfection

Source

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Identifiers

PMID: 22183808
DOI: 10.1007/s13238-011-1116-0
PMCID: PMC4875245

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-22183808-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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