Article
Desensitization of P2X2 receptor/channel pore mutants.
European journal of pharmacology - 8 Jul 2004
Nakazawa Ken, Ohno Yasuo
Abstract excerpt
Properties of five mutants of P2X2 receptor/channel having amino acid residue-substitution at the pore region were examined by expressing the channels in Xenopus oocytes. When the concentration-response relationship for ATP-evoked current was obtained, the current amplitude was increased along with the concentrations of ATP for the wild type channel whereas the amplitude was rather decreased with highest...
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