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Article

Ligand sensitivity of type-1 inositol 1,4,5-trisphosphate receptor is enhanced by the D2594K mutation.

Pflugers Archiv : European journal of physiology - 1 May 2023

Tambeaux Allison, Aguilar-Sánchez Yuriana, Santiago Demetrio J, Mascitti Madeleine, DiNovo Karyn M, Mejía-Alvarez Rafael, Fill Michael, Wayne Chen S R, Ramos-Franco Josefina

Abstract excerpt

Inositol 1,4,5-trisphosphate receptor (IP3R) and ryanodine receptor (RyR) are homologous cation channels that mediate release of Ca2+ from the endoplasmic/sarcoplasmic reticulum (ER/SR) and thereby are involved in many physiological processes. In previous studies, we determined that when the D2594 residue, located at or near the gate of the IP3R type 1, was replaced by lysine (D2594K), a gain of function was...

Topics

Inositol 1,4,5-Trisphosphate Receptors
Ligands
Calcium Signaling
Mutation
Endoplasmic Reticulum
Calcium

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 36881190
DOI: 10.1007/s00424-023-02796-x
PMCID: PMC10105685

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-36881190-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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