Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Critical regions for activation gating of the inositol 1,4,5-trisphosphate receptor.

The Journal of biological chemistry - 9 May 2003

Uchida Keiko, Miyauchi Hiroshi, Furuichi Teiichi, Michikawa Takayuki, Mikoshiba Katsuhiko

Abstract excerpt

To understand the molecular mechanism of ligand-induced gating of the inositol 1,4,5-trisphosphate (IP(3)) receptor (IP(3)R)/Ca(2+) release channel, we analyzed the channel properties of deletion mutants retaining both the IP(3)-binding and channel-forming domains of IP(3)R1. Using intrinsically IP(3)R-deficient cells as the host cells for receptor expression, we determined that six of the mutants, those lacking...

Topics

Amino Acid Sequence
Animals
Binding Sites
Calcium Channels
Conserved Sequence
Cysteine
Inositol 1,4,5-Trisphosphate Receptors
Ion Channel Gating
Ligands
Mice
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagenesis, Site-Directed

Mutation

Protein Structure, Tertiary

Receptors, Cytoplasmic and Nuclear

Source

Identifiers

PMID: 12621039
DOI: 10.1074/jbc.M300646200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-12621039-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Critical regions for activation gating of the inositol 1,4,5-trisphosphate receptor.PMID 12621039Read ↗

Tyr-167/Trp-168 in type 1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and channel opening.Semantic proximity Read ↗

Structural studies of inositol 1,4,5-trisphosphate receptor: coupling ligand binding to channel gating.Semantic proximity Read ↗

Ligand sensitivity of type-1 inositol 1,4,5-trisphosphate receptor is enhanced by the D2594K mutation.Semantic proximity Read ↗

Location of the permeation pathway in the recombinant type 1 inositol 1,4,5-trisphosphate receptor.Semantic proximity Read ↗

Molecular determinants of ion permeation and selectivity in inositol 1,4,5-trisphosphate receptor Ca2+ channels.Semantic proximity Read ↗

Functional properties of the Drosophila melanogaster inositol 1,4,5-trisphosphate receptor mutants.Semantic proximity Read ↗

Functional and biochemical analysis of the type 1 inositol (1,4,5)-trisphosphate receptor calcium sensor.Semantic proximity Read ↗

The Pro335 --> Leu polymorphism of type 3 inositol 1,4,5-trisphosphate receptor found in mouse inbred lines results in functional change.Semantic proximity Read ↗

Pathophysiological consequences of isoform-specific IP3 receptor mutations.Semantic proximity Read ↗

Disease-associated mutations in inositol 1,4,5-trisphosphate receptor subunits impair channel function.Semantic proximity Read ↗

A single lysine in the N-terminal region of store-operated channels is critical for STIM1-mediated gating.Semantic proximity Read ↗

A Gain-of-function Mutation in the Gating Domain of ITPR1 Impairs Motor Movement and Increases Thermal and Mechanical Sensitivity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.