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Article

Highly conserved tyrosine 37 stabilizes desensitized states and restricts calcium permeability of ATP-gated P2X3 receptor.

Journal of neurochemistry - 1 Nov 2011

Jindrichova Marie, Khafizov Kamil, Skorinkin Andrei, Fayuk Dmitriy, Bart Genevieve, Zemkova Hana, Giniatullin Rashid

Abstract excerpt

Tyrosine 37 in the first transmembrane (TM1) domain is highly conserved in ATP-gated P2X receptors suggesting its fundamental role. We tested whether Y37 contributes to the desensitization of P2X3 receptors, which is currently not well understood. By combining electrophysiological, imaging and modeling approaches, we studied desensitization of various Y37 P2X3 mutants and potential partners of Y37. Unlike the...

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PMID: 21883226
DOI: 10.1111/j.1471-4159.2011.07463.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Highly conserved tyrosine 37 stabilizes desensitized states and restricts calcium permeability of ATP-gated P2X3 receptor.PMID 21883226Read ↗

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