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Article

An essential role of PI(4,5)P₂ for maintaining the activity of the transient receptor potential canonical (TRPC)4β.

Pflugers Archiv : European journal of physiology - 1 Jul 2013

Kim Hana, Jeon Jae-Pyo, Hong Chansik, Kim Jinsung, Myeong Jongyoun, Jeon Ju-Hong, So Insuk

Abstract excerpt

The transient receptor potential canonical 4 (TRPC4) channel is a Ca(2+)-permeable nonselective cation channel in mammalian cells and mediates a number of cellular functions. Many studies show that TRPC channels are activated by stimulation of Gαq-phospholipase C (PLC)-coupled receptors. However, our previous study showed that the TRPC4 current was inhibited by co-expression of a constitutively active form of Gαq...

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Identifiers

PMID: 23417604
DOI: 10.1007/s00424-013-1236-x

Genes

TRPC4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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An essential role of PI(4,5)P₂ for maintaining the activity of the transient receptor potential canonical (TRPC)4β.PMID 23417604Read ↗

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