Article
TRPC3 controls agonist-stimulated intracellular Ca2+ release by mediating the interaction between inositol 1,4,5-trisphosphate receptor and RACK1.
The Journal of biological chemistry - 21 Nov 2008
Bandyopadhyay Bidhan C, Ong Hwei L, Lockwich Timothy P, Liu Xibao, Paria Biman C, Singh Brij B, Ambudkar Indu S
Abstract excerpt
Activation of TRPC3 channels is concurrent with inositol 1,4,5-trisphosphate (IP(3)) receptor (IP(3)R)-mediated intracellular Ca(2+) release and associated with phosphatidylinositol 4,5-bisphosphate hydrolysis and recruitment to the plasma membrane. Here we report that interaction of TRPC3 with r...
Topics
- Amino Acid Sequence
- Biotinylation
- Calcium
- Electrophysiology
- GTP-Binding Proteins
- Humans
- Inositol 1,4,5-Trisphosphate Receptors
- Microscopy, Confocal
- Models, Biological
- Molecular Sequence Data
- Mutation
- Neoplasm Proteins
- Oscillometry