Article
Involvement of the cysteine-rich head domain in activation and desensitization of the P2X1 receptor.
Proceedings of the National Academy of Sciences of the United States of America - 10 Jul 2012
Lörinczi Éva, Bhargava Yogesh, Marino Stephen F, Taly Antoine, Kaczmarek-Hájek Karina, Barrantes-Freer Alonso, Dutertre Sébastien, Grutter Thomas, Rettinger Jürgen, Nicke Annette
Abstract excerpt
P2X receptors (P2XRs) are ligand-gated ion channels activated by extracellular ATP. Although the crystal structure of the zebrafish P2X4R has been solved, the exact mode of ATP binding and the conformational changes governing channel opening and desensitization remain unknown. Here, we used voltage clamp fluorometry to investigate movements in the cysteine-rich head domain of the rat P2X1R (A118-I125) that...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.