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Article

Functional and biochemical analysis of the type 1 inositol (1,4,5)-trisphosphate receptor calcium sensor.

Biophysical journal - 1 Jul 2003

Tu Huiping, Nosyreva Elena, Miyakawa Tomoya, Wang Zhengnan, Mizushima Akiko, Iino Masamitsu, Bezprozvanny Ilya

Abstract excerpt

Modulation of the type 1 inositol (1,4,5)-trisphosphate receptors (InsP(3)R1) by cytosolic calcium (Ca(2+)) plays an essential role in their signaling function, but structural determinants and mechanisms responsible for the InsP(3)R1 regulation by Ca(2+) are poorly understood. Using DT40 cell expression system and Ca(2+) imaging assay, in our previous study we identified a critical role of E2100 residue in the...

Topics

Amino Acid Sequence
Animals
Binding Sites
Calcium
Calcium Channels
Calcium Signaling
Cells, Cultured
Inositol 1,4,5-Trisphosphate Receptors
Ion Channel Gating
Membrane Potentials

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Protein Binding

Protein Conformation

Protein Structure, Tertiary

Receptors, Cytoplasmic and Nuclear

Recombinant Proteins

Spodoptera

Source

Open in PubMed Open full text

Identifiers

PMID: 12829484
DOI: 10.1016/S0006-3495(03)74474-9
PMCID: PMC1303085

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-12829484-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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