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Article

Functional and biochemical analysis of the type 1 inositol (1,4,5)-trisphosphate receptor calcium sensor.

Biophysical journal - 1 Jul 2003

Tu Huiping, Nosyreva Elena, Miyakawa Tomoya, Wang Zhengnan, Mizushima Akiko, Iino Masamitsu, Bezprozvanny Ilya

Abstract excerpt

Modulation of the type 1 inositol (1,4,5)-trisphosphate receptors (InsP(3)R1) by cytosolic calcium (Ca(2+)) plays an essential role in their signaling function, but structural determinants and mechanisms responsible for the InsP(3)R1 regulation by Ca(2+) are poorly understood. Using DT40 cell expression system and Ca(2+) imaging assay, in our previous study we identified a critical role of E2100 residue in the...

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PMID: 12829484
DOI: 10.1016/S0006-3495(03)74474-9
PMCID: PMC1303085

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