Article
Relationship between minority nonnucleoside reverse transcriptase inhibitor resistance mutations, adherence, and the risk of virologic failure.
AIDS (London, England) - 14 Jan 2012
Li Jonathan Z, Paredes Roger, Ribaudo Heather J, Svarovskaia Evguenia S, Kozal Michael J, Hullsiek Katherine H, Miller Michael D, Bangsberg David R, Kuritzkes Daniel R
Abstract excerpt
OBJECTIVES: To evaluate the risk of virologic failure conferred by suboptimal adherence to nonnucleoside reverse transcriptase inhibitors (NNRTIs) and minority NNRTI resistance mutations. DESIGN: Pooled analysis of the risk of virologic failure conferred by minority NNRTI resistance mutations and NNRTI adherence from three studies of treatment-naïve individuals initiating an NNRTI-based regimen. METHODS:...
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