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Article

Low-frequency HIV-1 drug resistance mutations and risk of NNRTI-based antiretroviral treatment failure: a systematic review and pooled analysis.

JAMA - 6 Apr 2011

Li Jonathan Z, Paredes Roger, Ribaudo Heather J, Svarovskaia Evguenia S, Metzner Karin J, Kozal Michael J, Hullsiek Kathy Huppler, Balduin Melanie, Jakobsen Martin R, Geretti Anna Maria, Thiebaut Rodolphe, Ostergaard Lars, Masquelier Bernard, Johnson Jeffrey A, Miller Michael D, Kuritzkes Daniel R

Abstract excerpt

CONTEXT: Presence of low-frequency, or minority, human immunodeficiency virus type 1 (HIV-1) drug resistance mutations may adversely affect response to antiretroviral treatment (ART), but evidence regarding the effects of such mutations on the effectiveness of first-line ART is conflicting. OBJEC...

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Source

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Identifiers

PMID: 21467286
DOI: 10.1001/jama.2011.375
PMCID: PMC3325645

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21467286-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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