Article
Adherence-resistance relationships for protease and non-nucleoside reverse transcriptase inhibitors explained by virological fitness.
AIDS (London, England) - 9 Jan 2006
Bangsberg David R, Acosta Edward P, Gupta Reena, Guzman David, Riley Elise D, Harrigan P Richard, Parkin Neil, Deeks Steven G
Abstract excerpt
OBJECTIVE: To compare the prevalence of resistance by adherence level in patients treated with non-nucleoside reverse transcriptase inhibitors (NNRTI) or protease inhibitors (PI). Also to examine the mechanism of differential class-specific adherence-resistance relationships, focusing on the patient-derived capacity of wild-type and drug-resistant recombinant variants to replicate in vitro in the presence of...
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