Impact of Human Immunodeficiency Virus Type 1 Minority Variants on the Virus Response to a Rilpivirine-Based First-line Regimen.

doi:10.1093/cid/cix1070

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Article

Impact of Human Immunodeficiency Virus Type 1 Minority Variants on the Virus Response to a Rilpivirine-Based First-line Regimen.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 2 May 2018

Raymond Stéphanie, Nicot Florence, Pallier Coralie, Bellecave Pantxika, Maillard Anne, Trabaud Mary Anne, Morand-Joubert Laurence, Rodallec Audrey, Amiel Corinne, Mourez Thomas, Bocket Laurence, Beby-Defaux Agnès, Bouvier-Alias Magali, Lambert-Niclot Sidonie, Charpentier Charlotte, Malve Brice, Mirand Audrey, Dina Julia, Le Guillou-Guillemette Hélène, Marque-Juillet Stéphanie, Signori-Schmuck Anne, Barin Francis, Si-Mohamed Ali, Avettand Fenoel Véronique, Roussel Catherine, Calvez Vincent, Saune Karine, Marcelin Anne Geneviève, Rodriguez Christophe, Descamps Diane, Izopet Jacques

Abstract excerpt

Background: Minority resistant variants of human immunodeficiency virus type 1 (HIV-1) could influence the virological response to treatment based on nonnucleoside reverse transcriptase inhibitors (NNRTIs). Data on minority rilpivirine-resistant variants are scarce. This study used next-generation sequencing (NGS) to identify patients harboring minority resistant variants to nucleos(t)ide reverse transcriptase...

Topics

Adult
Drug Resistance, Viral
Female
Genetic Variation
HIV Infections
HIV-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Male

Mutation

Rilpivirine

Viral Load

Source

Open in PubMed Open full text

Identifiers

PMID: 29244143
DOI: 10.1093/cid/cix1070
PMCID: PMC7958925

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