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Article

Minority HIV-1 drug resistance mutations are present in antiretroviral treatment-naïve populations and associate with reduced treatment efficacy.

PLoS medicine - 29 Jul 2008

Johnson Jeffrey A, Li Jin-Fen, Wei Xierong, Lipscomb Jonathan, Irlbeck David, Craig Charles, Smith Amanda, Bennett Diane E, Monsour Michael, Sandstrom Paul, Lanier E Randall, Heneine Walid

Abstract excerpt

BACKGROUND: Transmitted HIV-1 drug resistance can compromise initial antiretroviral therapy (ART); therefore, its detection is important for patient management. The absence of drug-associated selection pressure in treatment-naïve persons can cause drug-resistant viruses to decline to levels undetectable by conventional bulk sequencing (minority drug-resistant variants). We used sensitive and simple tests to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18666824
DOI: 10.1371/journal.pmed.0050158
PMCID: PMC2488194

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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