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Article

Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart.

Circulation research - 1 Jan 2000

Eckhart A D, Duncan S J, Penn R B, Benovic J L, Lefkowitz R J, Koch W J

Abstract excerpt

G protein-coupled receptor kinases (GRKs) phosphorylate activated G protein-coupled receptors, including alpha(1B)-adrenergic receptors (ARs), resulting in desensitization. In vivo analysis of GRK substrate selectivity has been limited. Therefore, we generated hybrid transgenic mice with myocardium-targeted overexpression of 1 of 3 GRKs expressed in the heart (GRK2 [commonly known as the beta-AR kinase 1], GRK3,...

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Source

Identifiers

PMID: 10625304
DOI: 10.1161/01.res.86.1.43

Genes

GRK2
GRK3
GRK5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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