G protein-coupled receptor kinases (GRKs) orchestrate biased agonism at the β2-adrenergic receptor.

doi:10.1126/scisignal.aar7084

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Article

G protein-coupled receptor kinases (GRKs) orchestrate biased agonism at the β2-adrenergic receptor.

Science signaling - 21 Aug 2018

Choi Minjung, Staus Dean P, Wingler Laura M, Ahn Seungkirl, Pani Biswaranjan, Capel William D, Lefkowitz Robert J

Abstract excerpt

Biased agonists of G protein-coupled receptors (GPCRs), which selectively activate either G protein- or β-arrestin-mediated signaling pathways, are of major therapeutic interest because they have the potential to show improved efficacy and specificity as drugs. Efforts to understand the mechanistic basis of this phenomenon have focused on the hypothesis that G proteins and β-arrestins preferentially couple to...

Topics

Cell Line, Tumor
Extracellular Signal-Regulated MAP Kinases
G-Protein-Coupled Receptor Kinases
GTP-Binding Proteins
HEK293 Cells
Humans
Mutation
Phosphorylation
Receptors, Adrenergic, beta-2
Receptors, G-Protein-Coupled
Signal Transduction
beta-Arrestins

Source

Open in PubMed

Identifiers

PMID: 30131371
DOI: 10.1126/scisignal.aar7084

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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