Article
Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice.
The Journal of clinical investigation - 1 Nov 2005
Zhai Peiyong, Yamamoto Mitsutaka, Galeotti Jonathan, Liu Jing, Masurekar Malthi, Thaisz Jill, Irie Keiichi, Holle Eric, Yu Xianzhong, Kupershmidt Sabina, Roden Dan M, Wagner Thomas, Yatani Atsuko, Vatner Dorothy E, Vatner Stephen F, Sadoshima Junichi
Abstract excerpt
Ang II type 1 (AT1) receptors activate both conventional heterotrimeric G protein-dependent and unconventional G protein-independent mechanisms. We investigated how these different mechanisms activated by AT1 receptors affect growth and death of cardiac myocytes in vivo. Transgenic mice with cardiac-specific overexpression of WT AT1 receptor (AT1-WT; Tg-WT mice) or an AT1 receptor second intracellular loop mutant...
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