Article
Targeted transgenesis reveals discrete attenuator functions of GRK and PKA in airway beta2-adrenergic receptor physiologic signaling.
Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 2009
Wang Wayne C H, Mihlbachler Kathryn A, Brunnett Alicyn C, Liggett Stephen B
Abstract excerpt
Phosphorylation by protein kinase A (PKA) and G protein-coupled receptor kinases (GRKs) desensitize beta2-adrenergic receptor (beta2AR) signaling, and these are thought to be mechanisms involved with cell and organ homeostasis and tolerance to agonists. However, there is little direct evidence that these events are relevant to beta2AR physiological function, such as airway smooth muscle (ASM) relaxation leading...
Topics
- Adrenergic beta-2 Receptor Agonists
- Animals
- Cells, Cultured
- Cyclic AMP
- Cyclic AMP-Dependent Protein Kinases
- G-Protein-Coupled Receptor Kinases
- Humans
- Mice
- Mice, Transgenic
- Muscle, Smooth