Article
Plasmacytoid dendritic cells are crucial for the initiation of inflammation and T cell immunity in vivo.
Immunity - 23 Dec 2011
Takagi Hideaki, Fukaya Tomohiro, Eizumi Kawori, Sato Yumiko, Sato Kaori, Shibazaki Azusa, Otsuka Haruna, Hijikata Atsushi, Watanabe Takashi, Ohara Osamu, Kaisho Tsuneyasu, Malissen Bernard, Sato Katsuaki
Abstract excerpt
Plasmacytoid dendritic cells (pDCs) are characterized as type I interferon-producing cells that engage endosomal toll-like receptors (TLRs) and exclusively express sialic acid binding Ig-like lectin (Siglec)-H. However, their role in vivo remains unclear. Here we report a critical role for pDCs in the regulation of inflammation and T cell immunity in vivo by using gene-targeted mice with a deficiency of Siglec-H...
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