Article
Organ-dependent in vivo priming of naive CD4+, but not CD8+, T cells by plasmacytoid dendritic cells.
The Journal of experimental medicine - 6 Aug 2007
Sapoznikov Anita, Fischer Jens A A, Zaft Tami, Krauthgamer Rita, Dzionek Andrzej, Jung Steffen
Abstract excerpt
Plasmacytoid dendritic cells (PDCs) play a pivotal role as cytokine-secreting accessory cells in the antimicrobial immune defense. In contrast, the capacity of PDCs to act as antigen-presenting cells in naive T cell priming remains unclear. By studying T cell responses in mice that lack conventio...
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