Article
Plasmacytoid dendritic cells: key players in the initiation and regulation of immune responses.
Annals of the New York Academy of Sciences - 1 Jan 2010
Lande Roberto, Gilliet Michel
Abstract excerpt
Plasmacytoid dendritic cells (pDCs) are a rare population of circulating cells that selectively express Toll-like receptors (TLR)7 and TLR9 and have the capacity to produce large amounts of type I interferons (IFNs) in response to viruses or host-derived nucleic acid-containing complexes. Through the production of type I IFNs, pDCs initiate protective immunity by activating classical DCs, T cells, natural killer...
Topics
- Animals
- Cell Differentiation
- Cell Movement
- Dendritic Cells
- Disease
- Humans
- Immune System Phenomena
- Immunity, Innate
- Models, Biological
- Phenotype