Article
Novel mouse models based on intersectional genetics to identify and characterize plasmacytoid dendritic cells.
Nature immunology - 1 Apr 2023
Valente Michael, Collinet Nils, Vu Manh Thien-Phong, Popoff Dimitri, Rahmani Khalissa, Naciri Karima, Bessou Gilles, Rua Rejane, Gil Laurine, Mionnet Cyrille, Milpied Pierre, Tomasello Elena, Dalod Marc
Abstract excerpt
Plasmacytoid dendritic cells (pDCs) are the main source of type I interferon (IFN-I) during viral infections. Their other functions are debated, due to a lack of tools to identify and target them in vivo without affecting pDC-like cells and transitional DCs (tDCs), which harbor overlapping phenotypes and transcriptomes but a higher efficacy for T cell activation. In the present report, we present a reporter...
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