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Article

IRF7 regulates TLR2-mediated activation of splenic CD11c(hi) dendritic cells.

PloS one - 1 Jan 2012

Owens Benjamin M J, Moore John W J, Kaye Paul M

Abstract excerpt

Members of the Interferon Regulatory Factor (IRF) family of transcription factors play an essential role in the development and function of the immune system. Here we investigated the role of IRF7 in the functional activation of conventional CD11c(hi) splenic dendritic cells (cDCs) in vitro and in vivo. Using mice deficient in IRF7, we found that this transcription factor was dispensable for the in vivo...

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Identifiers

PMID: 22815909
DOI: 10.1371/journal.pone.0041050
PMCID: PMC3398003

Genes

TLR2

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