Article

Plasmacytoid dendritic cells are dispensable or detrimental in murine systemic or respiratory viral infections

2024-05-21

Abstract excerpt

Plasmacytoid dendritic cells (pDCs) are major producers of type I/III interferons. As interferons are crucial for antiviral defense, pDCs are assumed to play an essential role in this process. However, robust evidence supporting this dogma is scarce. Genetic or pharmacological manipulations that eliminate pDC or disrupt their interferon production often affect other cells, confounding interpretation. To overcome t...

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Literature Corpus work: 878e8f7e-bda7-5a3d-bbef-4b634249a530
DOI: 10.1101/2024.05.20.594961

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