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Article

Spi-B is critical for plasmacytoid dendritic cell function and development.

Blood - 6 Dec 2012

Sasaki Izumi, Hoshino Katsuaki, Sugiyama Takahiro, Yamazaki Chihiro, Yano Takahiro, Iizuka Akihiko, Hemmi Hiroaki, Tanaka Takashi, Saito Masuyoshi, Sugiyama Masanaka, Fukuda Yuri, Ohta Tomokazu, Sato Katsuaki, Ainai Akira, Suzuki Tadaki, Hasegawa Hideki, Toyama-Sorimachi Noriko, Kohara Hiroshi, Nagasawa Takashi, Kaisho Tsuneyasu

Abstract excerpt

Plasmacytoid dendritic cells (pDCs), originating from hematopoietic progenitor cells in the BM, are a unique dendritic cell subset that can produce large amounts of type I IFNs by signaling through the nucleic acid-sensing TLR7 and TLR9 (TLR7/9). The molecular mechanisms for pDC function and development remain largely unknown. In the present study, we focused on an Ets family transcription factor, Spi-B, that is...

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Source

Identifiers

PMID: 23065153
DOI: 10.1182/blood-2012-06-436527

Genes

TLR7
TLR9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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