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Article

Rab3 dynamically controls protein composition at active zones.

Neuron - 10 Dec 2009

Graf Ethan R, Daniels Richard W, Burgess Robert W, Schwarz Thomas L, DiAntonio Aaron

Abstract excerpt

Synaptic transmission requires the localization of presynaptic release machinery to active zones. Mechanisms regulating the abundance of such synaptic proteins at individual release sites are likely determinants of site-specific synaptic efficacy. We now identify a role for the small GTPase Rab3 in regulating the distribution of presynaptic components to active zones. At Drosophila rab3 mutant NMJs, the...

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Identifiers

PMID: 20005823
DOI: 10.1016/j.neuron.2009.11.002
PMCID: PMC2796257

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Rab3 dynamically controls protein composition at active zones.PMID 20005823Read ↗

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Rab3a is involved in transport of synaptic vesicles to the active zone in mouse brain nerve terminals.Semantic proximity Read ↗

RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone.Semantic proximity Read ↗

Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca(2+) channel-vesicle coupling.Semantic proximity Read ↗

Unc-51 controls active zone density and protein composition by downregulating ERK signaling.Semantic proximity Read ↗

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