Rab3 dynamically controls protein composition at active zones.

doi:10.1016/j.neuron.2009.11.002

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Article

Rab3 dynamically controls protein composition at active zones.

Neuron - 10 Dec 2009

Graf Ethan R, Daniels Richard W, Burgess Robert W, Schwarz Thomas L, DiAntonio Aaron

Abstract excerpt

Synaptic transmission requires the localization of presynaptic release machinery to active zones. Mechanisms regulating the abundance of such synaptic proteins at individual release sites are likely determinants of site-specific synaptic efficacy. We now identify a role for the small GTPase Rab3 in regulating the distribution of presynaptic components to active zones. At Drosophila rab3 mutant NMJs, the...

Topics

Animals
Animals, Genetically Modified
Calcium
Drosophila
Drosophila Proteins
Excitatory Postsynaptic Potentials
Gene Expression Regulation
Green Fluorescent Proteins
Microscopy, Electron, Transmission
Motor Endplate
Mutation
Neuromuscular Junction
Nonlinear Dynamics
Presynaptic Terminals
Receptors, Glutamate
rab3 GTP-Binding Proteins

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Identifiers

PMID: 20005823
DOI: 10.1016/j.neuron.2009.11.002
PMCID: PMC2796257

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