Article
Rab3-GEF Controls Active Zone Development at the Drosophila Neuromuscular Junction.
eNeuro - 1 Jan 2000
Bae Haneui, Chen Shirui, Roche John P, Ai Minrong, Wu Chunlai, Diantonio Aaron, Graf Ethan R
Abstract excerpt
Synaptic signaling involves the release of neurotransmitter from presynaptic active zones (AZs). Proteins that regulate vesicle exocytosis cluster at AZs, composing the cytomatrix at the active zone (CAZ). At the Drosophila neuromuscular junction (NMJ), the small GTPase Rab3 controls the distribution of CAZ proteins across release sites, thereby regulating the efficacy of individual AZs. Here we identify Rab3-GEF...
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