Article
Amino acid position 11 of HLA-DRβ1 is a major determinant of chromosome 6p association with ulcerative colitis.
Genes and immunity - 1 Apr 2012
Achkar J-P, Klei L, de Bakker P I W, Bellone G, Rebert N, Scott R, Lu Y, Regueiro M, Brzezinski A, Kamboh M I, Fiocchi C, Devlin B, Trucco M, Ringquist S, Roeder K, Duerr R H
Abstract excerpt
The major histocompatibility complex (MHC) on chromosome 6p is an established risk locus for ulcerative colitis (UC) and Crohn's disease (CD). We aimed to better define MHC association signals in UC and CD by combining data from dense single-nucleotide polymorphism (SNP) genotyping and from imputation of classical human leukocyte antigen (HLA) types, their constituent SNPs and corresponding amino acids in 562 UC,...
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