Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The HLA-DRβ1 amino acid positions 11-13-26 explain the majority of SLE-MHC associations.

Nature communications - 23 Dec 2014

Kim Kwangwoo, Bang So-Young, Lee Hye-Soon, Okada Yukinori, Han Buhm, Saw Woei-Yuh, Teo Yik-Ying, Bae Sang-Cheol

Abstract excerpt

Genetic association of the major histocompatibility complex (MHC) locus is well established in systemic lupus erythematosus (SLE), but the causal functional variants in this region have not yet been discovered. Here we conduct the first fine-mapping study, which thoroughly investigates the SLE-MH...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Asian People
Share to Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Haplotypes

Share to HLA-DRB1 Chains

Share to Lupus Erythematosus, Systemic

Share to Protein Binding

Share to Republic of Korea

Source

Identifiers

PMID: 25533202
DOI: 10.1038/ncomms6902

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25533202-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The HLA-DRβ1 amino acid positions 11-13-26 explain the majority of SLE-MHC associations.PMID 25533202Read ↗

Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis.Semantic proximity Read ↗

Amino acid signatures of HLA Class-I and II molecules are strongly associated with SLE susceptibility and autoantibody production in Eastern AsiansSemantic proximity Read ↗

Fine-mapping SLE-MHC associations revealed independent contributions of HLA missense variants and<i>C4</i>copy number variationsSemantic proximity Read ↗

Fine-mapping the human leukocyte antigen locus in rheumatoid arthritis and other rheumatic diseases: identifying causal amino acid variants?Semantic proximity Read ↗

The influence of functional polymorphic positions of HLA-DRβ1 molecules on risk for South Indian systemic lupus erythematosus patients.Semantic proximity Read ↗

Imputing Variants in HLA-DR Beta Genes Reveals That HLA-DRB1 Is Solely Associated with Rheumatoid Arthritis and Systemic Lupus Erythematosus.Semantic proximity Read ↗

High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.Semantic proximity Read ↗

The amino acid variants in HLA II molecules explain the major association with adult-onset Still's disease in the Han Chinese population.Semantic proximity Read ↗

Risk for ACPA-positive rheumatoid arthritis is driven by shared HLA amino acid polymorphisms in Asian and European populations.Semantic proximity Read ↗

MHC region and risk of systemic lupus erythematosus in African American women.Semantic proximity Read ↗

The susceptible HLA class II alleles and their presenting epitope(s) in Goodpasture's disease.Semantic proximity Read ↗

Amino acid position 37 of HLA-DRβ1 affects susceptibility to Crohn's disease in Asians.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.