Article
Inflammatory bowel disease is linked to 19p13 and associated with ICAM-1.
Inflammatory bowel diseases - 1 May 2004
Low Jin Hong, Williams Fiona A, Yang Xuesong, Cullen Sue, Colley James, Ling Khoon Lin, Armuzzi Alessandro, Ahmad Tariq, Neville Matt J, Dechairo Bryan M, Walton Robert, Lench Nick J, Jewell Derek P
Abstract excerpt
Genome-wide scans have implicated several susceptibility loci, but linkage of 19p13 (IBD6) to Crohn's disease (CD) has not been fully replicated. We report a replication study of IBD6 in a UK Caucasian population. Two hundred eighty-four affected sibling pairs from 234 families were used for the linkage study. Linkage between IBD6 linkage and CD was replicated (LOD score = 1.59). Two candidate genes (DDXL and...
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