Article
Clustering and alignment of polymorphic sequences for HLA-DRB1 genotyping.
PloS one - 1 Jan 2013
Ringquist Steven, Bellone Gaia, Lu Ying, Roeder Kathryn, Trucco Massimo
Abstract excerpt
Located on Chromosome 6p21, classical human leukocyte antigen genes are highly polymorphic. HLA alleles associate with a variety of phenotypes, such as narcolepsy, autoimmunity, as well as immunologic response to infectious disease. Moreover, high resolution genotyping of these loci is critical to achieving long-term survival of allogeneic transplants. Development of methods to obtain high resolution analysis of...
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