Article
CEACAM6 gene variants in inflammatory bowel disease.
PloS one - 29 Apr 2011
Glas Jürgen, Seiderer Julia, Fries Christoph, Tillack Cornelia, Pfennig Simone, Weidinger Maria, Beigel Florian, Olszak Torsten, Lass Ulrich, Göke Burkhard, Ochsenkühn Thomas, Wolf Christiane, Lohse Peter, Müller-Myhsok Bertram, Diegelmann Julia, Czamara Darina, Brand Stephan
Abstract excerpt
BACKGROUND: The carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) acts as a receptor for adherent-invasive E. coli (AIEC) and its ileal expression is increased in patients with Crohn's disease (CD). Given its contribution to the pathogenesis of CD, we aimed to investigate the role of genetic variants in the CEACAM6 region in patients with inflammatory bowel diseases (IBD). METHODOLOGY: In this...
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