Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.

doi:10.1038/ng.275

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Article

Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.

Nature genetics - 1 Feb 2009

Silverberg Mark S, Cho Judy H, Rioux John D, McGovern Dermot P B, Wu Jing, Annese Vito, Achkar Jean-Paul, Goyette Philippe, Scott Regan, Xu Wei, Barmada M Michael, Klei Lambertus, Daly Mark J, Abraham Clara, Bayless Theodore M, Bossa Fabrizio, Griffiths Anne M, Ippoliti Andrew F, Lahaie Raymond G, Latiano Anna, Paré Pierre, Proctor Deborah D, Regueiro Miguel D, Steinhart A Hillary, Targan Stephan R, Schumm L Philip, Kistner Emily O, Lee Annette T, Gregersen Peter K, Rotter Jerome I, Brant Steven R, Taylor Kent D, Roeder Kathryn, Duerr Richard H

Abstract excerpt

Ulcerative colitis is a chronic inflammatory disease of the colon that presents as diarrhea and gastrointestinal bleeding. We performed a genome-wide association study using DNA samples from 1,052 individuals with ulcerative colitis and preexisting data from 2,571 controls, all of European ancestry. In an analysis that controlled for gender and population structure, ulcerative colitis loci attaining genome-wide...

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PMID: 19122664
DOI: 10.1038/ng.275
PMCID: PMC2652837

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