Dense genotyping of immune-related loci identifies HLA variants associated with increased risk of collagenous colitis.

doi:10.1136/gutjnl-2015-309934

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Article

Dense genotyping of immune-related loci identifies HLA variants associated with increased risk of collagenous colitis.

Gut - 1 Mar 2017

Westerlind Helga, Mellander Marie-Rose, Bresso Francesca, Munch Andreas, Bonfiglio Ferdinando, Assadi Ghazaleh, Rafter Joseph, Hübenthal Matthias, Lieb Wolfgang, Källberg Henrik, Brynedal Boel, Padyukov Leonid, Halfvarson Jonas, Törkvist Leif, Bjork Jan, Andreasson Anna, Agreus Lars, Almer Sven, Miehlke Stephan, Madisch Ahmed, Ohlsson Bodil, Löfberg Robert, Hultcrantz Rolf, Franke Andre, D'Amato Mauro

Abstract excerpt

OBJECTIVE: Collagenous colitis (CC) is a major cause of chronic non-bloody diarrhoea, particularly in the elderly female population. The aetiology of CC is unknown, and still poor is the understanding of its pathogenesis. This possibly involves dysregulated inflammation and immune-mediated reactions in genetically predisposed individuals, but the contribution of genetic factors to CC is underinvestigated. We...

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PMID: 26525574
DOI: 10.1136/gutjnl-2015-309934

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