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Article

Critical role for the tapasin-docking site of TAP2 in the functional integrity of the MHC class I-peptide-loading complex.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2005

Leonhardt Ralf M, Keusekotten Kirstin, Bekpen Cemalettin, Knittler Michael R

Abstract excerpt

The transporter associated with Ag processing (TAP) translocates antigenic peptides into the endoplasmic reticulum for binding onto MHC class I (MHC I) molecules. Tapasin organizes a peptide-loading complex (PLC) by recruiting MHC I and accessory chaperones to the N-terminal regions (N domains) of the TAP subunits TAP1 and TAP2. To investigate the function of the tapasin-docking sites of TAP in MHC I processing,...

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Source

Identifiers

PMID: 16210614
DOI: 10.4049/jimmunol.175.8.5104

Genes

TAP2
TAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Critical role for the tapasin-docking site of TAP2 in the functional integrity of the MHC class I-peptide-loading complex.PMID 16210614Read ↗

Assembly of tapasin-associated MHC class I in the absence of the transporter associated with antigen processing (TAP).Semantic proximity Read ↗

The cell biology of major histocompatibility complex class I assembly: towards a molecular understandingSemantic proximity Read ↗

Productive association between MHC class I and tapasin requires the tapasin transmembrane/cytosolic region and the tapasin C-terminal Ig-like domain.Semantic proximity Read ↗

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Recruitment of MHC class I molecules by tapasin into the transporter associated with antigen processing-associated complex is essential for optimal peptide loading.Semantic proximity Read ↗

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