Article
A mechanistic basis for the co-evolution of chicken tapasin and major histocompatibility complex class I (MHC I) proteins.
The Journal of biological chemistry - 8 Nov 2013
van Hateren Andy, Carter Rachel, Bailey Alistair, Kontouli Nasia, Williams Anthony P, Kaufman Jim, Elliott Tim
Abstract excerpt
MHC class I molecules display peptides at the cell surface to cytotoxic T cells. The co-factor tapasin functions to ensure that MHC I becomes loaded with high affinity peptides. In most mammals, the tapasin gene appears to have little sequence diversity and few alleles and is located distal to several classical MHC I loci, so tapasin appears to function in a universal way to assist MHC I peptide loading. In...
Topics
- Alleles
- Animals
- Chickens
- Evolution, Molecular
- Genetic Loci
- Histocompatibility Antigens Class I
- Humans
- Membrane Transport Proteins
- Protein Structure, Tertiary