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Article

Assembly of tapasin-associated MHC class I in the absence of the transporter associated with antigen processing (TAP).

International immunology - 1 Jan 2001

Paulsson K M, Anderson P O, Chen S, Sjögren H O, Ljunggren H G, Wang P, Li S

Abstract excerpt

The assembly of MHC class I molecules is regulated by a multi-protein complex in the endoplasmic reticules (ER) termed the loading complex. Tapasin is suggested to be one of the molecules forming this complex on the basis of its interaction with both the transporter associated with antigen processing (TAP) and MHC class I molecules. To address whether TAP is indispensable for the processing of the assembly of...

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Source

Identifiers

PMID: 11133831
DOI: 10.1093/intimm/13.1.23

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Assembly of tapasin-associated MHC class I in the absence of the transporter associated with antigen processing (TAP).PMID 11133831Read ↗

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Impaired assembly yet normal trafficking of MHC class I molecules in Tapasin mutant mice.Semantic proximity Read ↗

Productive association between MHC class I and tapasin requires the tapasin transmembrane/cytosolic region and the tapasin C-terminal Ig-like domain.Semantic proximity Read ↗

Dependence of peptide binding by MHC class I molecules on their interaction with TAP.Semantic proximity Read ↗

Recruitment of MHC class I molecules by tapasin into the transporter associated with antigen processing-associated complex is essential for optimal peptide loading.Semantic proximity Read ↗

Soluble tapasin restores MHC class I expression and function in the tapasin-negative cell line .220.Semantic proximity Read ↗

The cell biology of major histocompatibility complex class I assembly: towards a molecular understandingSemantic proximity Read ↗

Allele-specific differences in the interaction of MHC class I molecules with transporters associated with antigen processing.Semantic proximity Read ↗

HLA-B27-restricted antigen presentation in the absence of tapasin reveals polymorphism in mechanisms of HLA class I peptide loading.Semantic proximity Read ↗

The Transporter Associated With Antigen Processing (TAP): Structural Integrity, Expression, Function, and Its Clinical RelevanceSemantic proximity Read ↗

Diversity of natural self-derived ligands presented by different HLA class I molecules in transporter antigen processing-deficient cells.Semantic proximity Read ↗

Roles for calreticulin and a novel glycoprotein, tapasin, in the interaction of MHC class I molecules with TAP.Semantic proximity Read ↗

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