Article
A region of tapasin that affects L(d) binding and assembly.
Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2001
Turnquist H R, Vargas S E, Reber A J, McIlhaney M M, Li S, Wang P, Sanderson S D, Gubler B, van Endert P, Solheim J C
Abstract excerpt
Tapasin has been shown to stabilize TAP and to link TAP to the MHC class I H chain. Evidence also has been presented that tapasin influences the loading of peptides onto MHC class I. To explore the relationship between the ability of tapasin to bind to TAP and the MHC class I H chain and the ability of tapasin to facilitate class I assembly, we have created novel tapasin mutants and expressed them in 721.220-L(d)...
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