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Article

Tyrosine phosphorylation of Rac1: a role in regulation of cell spreading.

PloS one - 1 Jan 2011

Chang Fumin, Lemmon Christopher, Lietha Daniel, Eck Michael, Romer Lewis

Abstract excerpt

Rac1 influences a multiplicity of vital cellular- and tissue-level control functions, making it an important candidate for targeted therapeutics. The activity of the Rho family member Cdc42 has been shown to be modulated by tyrosine phosphorylation at position 64. We therefore investigated consequences of the point mutations Y64F and Y64D in Rac1. Both mutations altered cell spreading from baseline in the...

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Identifiers

PMID: 22163037
DOI: 10.1371/journal.pone.0028587
PMCID: PMC3232246

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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