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Article

Rational design and applications of a Rac GTPase-specific small molecule inhibitor.

Methods in enzymology - 1 Jan 2006

Akbar Huzoor, Cancelas Jose, Williams David A, Zheng Jie, Zheng Yi

Abstract excerpt

Rac GTPases are involved in the regulation of multiple cell functions and have been implicated in the pathology of certain human diseases. Dominant negative mutants of Rac have been the tool of choice in studying Rac function in cells. Given the difficulty of introducing high concentrations of the Rac mutants into primary cells and nonspecific effects of the mutants on Rho guanine nucleotide exchange factor (GEF)...

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Identifiers

PMID: 16472687
DOI: 10.1016/S0076-6879(06)06043-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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