Article
The phosphomimetic mutation of syndecan-4 binds and inhibits Tiam1 modulating Rac1 activity in PDZ interaction-dependent manner.
PloS one - 1 Jan 2017
Keller-Pinter Aniko, Ughy Bettina, Domoki Monika, Pettko-Szandtner Aladar, Letoha Tamas, Tovari Jozsef, Timar Jozsef, Szilak Laszlo
Abstract excerpt
The small GTPases of the Rho family comprising RhoA, Rac1 and Cdc42 function as molecular switches controlling several essential biochemical pathways in eukaryotic cells. Their activity is cycling between an active GTP-bound and an inactive GDP-bound conformation. The exchange of GDP to GTP is catalyzed by guanine nucleotide exchange factors (GEFs). Here we report a novel regulatory mechanism of Rac1 activity,...
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