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Article

The C-terminal domain of Rac1 contains two motifs that control targeting and signaling specificity.

The Journal of biological chemistry - 3 Oct 2003

van Hennik Paula B, ten Klooster Jean Paul, Halstead Jon R, Voermans Carlijn, Anthony Eloise C, Divecha Nullin, Hordijk Peter L

Abstract excerpt

Rho-like GTPases control a wide range of cellular functions such as integrin- and cadherin-mediated adhesion, cell motility, and gene expression. The hypervariable C-terminal domain of these GTPases has been implicated in membrane association and effector binding. We found that cell-permeable peptides, encoding the C termini of Rac1, Rac2, RhoA, and Cdc42, interfere with GTPase signaling in a specific fashion in...

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Identifiers

PMID: 12874273
DOI: 10.1074/jbc.M307001200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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